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The Northwestern University Feinberg School of Medicine Division of Reproductive Endocrinology and Infertility has an extensive research enterprise. Each of our faculty members is involved in multiple research studies. In addition to lab studies, numerous clinical studies relate to various aspects of reproduction and infertility. In particular, we conduct studies associated with fertility preservation.
If you are a current patient and think you'd be a candidate for participation in one of our studies, please feel free to reach out to your Northwestern Medicine provider or our OBGYN REI clinical research team for more information.
PREGnant: Pre-IVF treatment with GnRH antagonist in women with Endometriosis – A prospective double-blind placebo-controlled trial
To determine whether live birth rates will improve in infertile women with endometriosis undergoing in vitro fertilization-embryo transfer (IVF-ET) when pretreated with an oral GnRH antagonist compared to placebo.
Polyps, Fibroids, and the Endometrial Microbiome: Is the endometrial microbiome altered among women with endometrial polyps or fibroids?
The purpose of this study is to assess whether the endometrial microbiome is different in women with endometrial polyps and/or fibroids compared to that of individuals without polyps or fibroids. If the endometrial microbiome is altered among women with polyps and/or fibroids, this association could help elucidate potential mechanisms by which polyps and fibroids impact fertility and could identify novel therapeutic targets for women afflicted by these conditions.
High Resolution Gene Expression Mapping of Polycystic Ovary Syndrome (PCOS) and Reproductively Normal Ovaries
The purpose of this study is to generate transcriptome maps of reproductively normal and PCOS ovaries to identify how the ovary’s molecular anatomy and its ability produce hormones are altered in PCOS. We are using a powerful new technology, single cell RNA-seq, on the cells/material obtained during an oocyte retrieval to develop a model to study the impact of PCOS on the biology of the ovary. This study will produce a multi-faceted insight into the structural and molecular function of a reproductively healthy human ovary and identify molecular pathologies of the PCOS ovary. This will lead to improved and novel treatment for this disorder.
PROMISE Study: Prospective mothers’ and infants’ social and epidemiologic determinants of health
To determine if preconceptional nutrition, physical activity, sleep, and/or stress are associated with time to pregnancy or fertility outcomes, adverse pregnancy outcomes, or adverse outcomes for children.
RAQUEL: Randomized trial assessing Quinagolide vaginal ring for endometriosis-related pain
This trial is a randomized, double-blind, placebo-controlled, phase 2 trial assessing the efficacy, safety and dose-response of Quinagolide extended-release non-hormonal vaginal rings administered sequentially for 4 menstrual cycles in women with moderate to severe endometriosis-related pain. This trial is being administered to evaluate the effect of this novel drug on reduction of endometriosis pain, ability to function, ovarian function, endocrine parameters, vaginal bleeding pattern, bone turnover markers, among other objectives.
Reproductive Tissue Library
The purpose of reproductive tissue collection is to collect varying reproductive tissue that would otherwise be discarded and/or blood samples. These specimens are used to support investigative research into the pathophysiology of reproductive tissue through the development of tissue cultures and other research works. We are currently working on projects looking at ovarian aging and endometriosis, amongst other studies.
RPL Psych: Medical and Psychosocial Factors Related to Recurrent Pregnancy Loss
The purpose of this study is to prospectively describe the psychological and dyadic adjustment of women and their partners with recurrent pregnancy loss. In this prospective study of couples with RPL, psychological and behavioral surveys are being administered to assess the impact of pregnancy and pregnancy loss on psychosocial measures of wellbeing in a prospective fashion.
Learn more about our research activities via the Feinberg School of Medicine Obstetrics and Gynecology research section.
To Request an Appointment
Northwestern Medicine Fertility Center is now conveniently located in three locations: Chicago, Highland Park, and Oakbrook Terrace.
Visit our Locations & Appointments page for more information.